Lab Members - Catherine S. Kaddis

Catherine

Catherine Kaddis' research involves the development of biophysical/biochemical techniques to characterize the structure of large protein complexes. The study of gas phase molecules may allow for the understanding of the intrinsic forces governing protein folding and interactions. The application of mass and ion mobility (GEMMA/Macro-IMS) spectrometry to measure size, and potentially shape, is especially important for proteins that are difficult to crystallize or are too large for NMR characterization.

Catherine earned her masters degree at CSULA and bachelors degree at UCLA. In the laboratory of Dr. F. A. Gomez (CSULA), Catherine worked on the development of bioanalytical techniques to study antibiotic-ligand interactions.

Kaddis CS and Loo JA. Native Protein Mass Spectrometry and Ion Mobility: ESI and Large Flying Proteins. Anal Chem 2007; 79: 1779-1784. (cover article)

Poderycki MJ, Kickhoefer VA, Kaddis CS, Raval-Fernandes S, Johansson E, Zink JI, Loo JA, and Rome LH. The Vault Exterior Shell is a Dynamic Structure that Allows Incorporation of Vault-Associated Proteins into its Interior. Biochemistry 2006; 45: 12184-12193.

Loo JA, Berhane BT, Kaddis CS, Wooding KM, Xie Y, Kaufman SL, and Chernushevich IV. Electrospray Ionization Mass Spectrometry and Ion Mobility Analysis of the 20S Proteasome Complex. J Am Soc Mass Spectrom 2005; 16: 998-1008.

Kani K, Warren CM, Kaddis CS, Loo JA, and Landgraf R. Oligomers of ErbB3 Have Two Distinct Interfaces That Differ in Their Sensitivity to Disruption by Heregulin. J Biol Chem 2005; 280: 8238-8247.